| First Author | Ozguldez HO | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 4 | Pages | 112313 |
| PubMed ID | 36989113 | Mgi Jnum | J:334840 |
| Mgi Id | MGI:7463811 | Doi | 10.1016/j.celrep.2023.112313 |
| Citation | Ozguldez HO, et al. (2023) Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage. Cell Rep 42(4):112313 |
| abstractText | The extra-embryonic tissues that form the placenta originate from a small population of trophectoderm cells with stem cell properties, positioned at the embryonic pole of the mouse blastocyst. During the implantation stages, the polar trophectoderm rapidly proliferates and transforms into extra-embryonic ectoderm. The current model of trophoblast morphogenesis suggests that tissue folding reshapes the trophoblast during the blastocyst to egg cylinder transition. Instead of through folding, here we found that the tissue scale architecture of the stem cell compartment of the trophoblast lineage is reorganized via inversion of the epithelial polarity axis. Our findings show the developmental significance of polarity inversion and provide a framework for the morphogenetic transitions in the peri-implantation trophoblast. |
