| First Author | Fu X | Year | 2015 |
| Journal | J Biol Chem | Volume | 290 |
| Issue | 44 | Pages | 26445-56 |
| PubMed ID | 26370082 | Mgi Jnum | J:315745 |
| Mgi Id | MGI:6830338 | Doi | 10.1074/jbc.M115.665232 |
| Citation | Fu X, et al. (2015) AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. J Biol Chem 290(44):26445-56 |
| abstractText | Satellite cells are the major myogenic stem cells residing inside skeletal muscle and are indispensable for muscle regeneration. Satellite cells remain largely quiescent but are rapidly activated in response to muscle injury, and the derived myogenic cells then fuse to repair damaged muscle fibers or form new muscle fibers. However, mechanisms eliciting metabolic activation, an inseparable step for satellite cell activation following muscle injury, have not been defined. We found that a noncanonical Sonic Hedgehog (Shh) pathway is rapidly activated in response to muscle injury, which activates AMPK and induces a Warburg-like glycolysis in satellite cells. AMPKalpha1 is the dominant AMPKalpha isoform expressed in satellite cells, and AMPKalpha1 deficiency in satellite cells impairs their activation and myogenic differentiation during muscle regeneration. Drugs activating noncanonical Shh promote proliferation of satellite cells, which is abolished because of satellite cell-specific AMPKalpha1 knock-out. Taken together, AMPKalpha1 is a critical mediator linking noncanonical Shh pathway to Warburg-like glycolysis in satellite cells, which is required for satellite activation and muscle regeneration. |
