Primary Identifier | MGI:3717121 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Sox17 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: Intracranial Aneurysm J:234137. |
molecularNote | LoxP sites were inserted on either side of the exon 3-5 region of the Sox17 gene. Mice homozygous for this allele are viable and fertile and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. |