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Allele : Tg(PDGFB-APPInd)H6Lms transgene insertion H6, Lennart Mucke
Primary Identifier  MGI:3717672 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(PDGFB-APPInd)H6Lms
Is Recombinase  false Is Wild Type  false
molecularNote  The transgene contains a human APP minigene encoding the Indiana mutation (V717F) which is associated with familial Alzheimer disease. The construct contained APP introns 6-8, allowing alternative splicing of exons 7 and 8. The human PDGF beta-chain promoter drives expression, and the construct also contains the SV40 polyadenylation signal. Amyloid-beta ELISA on whole brain homogenates indicates higher cerebral beta-amyloid production than in Tg(APPV717F)109Ili mice expressing the same construct.
  • mutations:
  • Insertion
  • synonyms:
  • APPInd,
  • Tg(PDGFB-APP*V717F)H6Lms,
  • PDGF-hAPP line 6,
  • Tg(PDGFB-APP*Ind)H6Lms,
  • Tg(PDGFB-APP*Ind)H6Lms,
  • PDGF-hAPP line 6,
  • Tg(PDGFB-APP*V717F)H6Lms,
  • PDGF-hAPP line H6,
  • PDGF-hAPP line H6,
  • APPInd
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories

Trail: Allele




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