| First Author | Li C | Year | 2018 |
| Journal | Cell | Volume | 174 |
| Issue | 2 | Pages | 285-299.e12 |
| PubMed ID | 29887374 | Mgi Jnum | J:265658 |
| Mgi Id | MGI:6193228 | Doi | 10.1016/j.cell.2018.05.004 |
| Citation | Li C, et al. (2018) TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype. Cell 174(2):285-299.e12 |
| abstractText | Visceral adipose tissue (VAT) hosts a population of regulatory T (Treg) cells, with a unique phenotype, that controls local and systemic inflammation and metabolism. Generation of a T cell receptor transgenic mouse line, wherein VAT Tregs are highly enriched, facilitated study of their provenance, dependencies, and activities. We definitively established a role for T cell receptor specificity, uncovered an unexpected function for the primordial Treg transcription-factor, Foxp3, evidenced a cell-intrinsic role for interleukin-33 receptor, and ordered these dependencies within a coherent scenario. Genesis of the VAT-Treg phenotype entailed a priming step in the spleen, permitting them to exit the lymphoid organs and surveil nonlymphoid tissues, and a final diversification process within VAT, in response to microenvironmental cues. Understanding the principles of tissue-Treg biology is a prerequisite for precision-targeting strategies. |
