Primary Identifier | MGI:3719472 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Erf |
Transmission | Germline | Strain of Origin | 129S4/SvJae-Tg(Prm-cre)70Og |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector replaced exons 2, 3 and part of exon 4, sequences that encode the DNA binding domain, with a floxed neomycin resistance cassette. Expression of a cre transgene carried by the parental ES cells removed the floxed neo cassette upon passage through the male germline. Northern blot confirmed absence of transcript in mutant mice. |