| Primary Identifier | MGI:3717234 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Ckm-PTPN1)45Bbk |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| description | Transgenic mice have impaired insulin-signaling and insulin-stimulated glucose uptake into skeletal muscle, resulting in impaired whole-body glucose homeostasis. |
| molecularNote | This transgene expresses the cDNA of the human isoform of protein tyrosine phosphatase 1B (PTPN1) from the mouse muscle creatine kinase promoter. Transgenic mice overexpress this construct 1.8 fold in skeletal muscle. No overexpression was detected in heart. |
