| Primary Identifier | MGI:3718996 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Col2a1-Mef2c/en)1Eno |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene expresses a fusion protein of the murine Mef2c DNA-binding domain and the Drosophila Engrailed repressor in proliferating chondrocytes under the control of the murine Col2a1 promoter. This Mef2c-engrailed fusion protein inactivates all Mef2 proteins by preventing DNA binding and creating transcriptionally inactive heterodimers with wild-type Mef2 proteins. |
