| First Author | Burikhanov R | Year | 2017 |
| Journal | Cell Rep | Volume | 18 |
| Issue | 2 | Pages | 508-519 |
| PubMed ID | 28076793 | Mgi Jnum | J:254044 |
| Mgi Id | MGI:6103694 | Doi | 10.1016/j.celrep.2016.12.051 |
| Citation | Burikhanov R, et al. (2017) Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis. Cell Rep 18(2):508-519 |
| abstractText | The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clinical trial. CQ-inducible Par-4 secretion triggers paracrine apoptosis of cancer cells and also inhibits metastatic tumor growth. CQ induces Par-4 secretion via the classical secretory pathway that requires the activation of p53. Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. Our findings indicate that CQ induces p53- and Rab8b-dependent Par-4 secretion from normal cells for Par-4-dependent inhibition of metastatic tumor growth. |
