| First Author | Xing Y | Year | 2021 |
| Journal | J Invest Dermatol | Volume | 141 |
| Issue | 5 | Pages | 1308-1316 |
| PubMed ID | 33091423 | Mgi Jnum | J:305032 |
| Mgi Id | MGI:6696414 | Doi | 10.1016/j.jid.2020.08.030 |
| Citation | Xing Y, et al. (2021) Visualizing the Itch-Sensing Skin Arbors. J Invest Dermatol 141(5):1308-1316 |
| abstractText | Diverse sensory neurons exhibit distinct neuronal morphologies with a variety of axon terminal arborizations subserving their functions. Because of its clinical significance, the molecular and cellular mechanisms of itch are being intensely studied. However, a complete analysis of itch-sensing terminal arborization is missing. Using an MrgprC11(CreERT2) transgenic mouse line, we labeled a small subset of itch-sensing neurons that express multiple itch-related molecules including MrgprA3, MrgprC11, histamine receptor H1, IL-31 receptor, 5-hydroxytryptamine receptor 1F, natriuretic precursor peptide B, and neuromedin B. By combining sparse genetic labeling and whole-mount placental alkaline phosphatase histochemistry, we found that itch-sensing skin arbors exhibit free endings with extensive axonal branching in the superficial epidermis and large receptive fields. These results revealed the unique morphological characteristics of itch-sensing neurons and provide intriguing insights into the basic mechanisms of itch transmission. |
