| Primary Identifier | MGI:3720356 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(APOE-DGAT2)24Far |
| Strain of Origin | C57BL/6NHsd | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The LivLE6-DGAT2 transgene was designed with promoter and enhancer sequences of the human apolipoprotein E gene placed upstream of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA sequence. This transgene was microinjected into C57BL/6NHsd fertilized eggs, and the resulting transgenic offspring were bred to C57BL/6NHsd. Mice from founder line 24 (referred to as Liv-DGAT2-low) have an approximately 2-fold increase in total hepatic DGAT2 mRNA/protein expression, with no reported overexpression in kidney, brain, or skeletal muscle. |
