| Primary Identifier | MGI:3757954 | Allele Type | Transgenic |
| Attribute String | Constitutively active, Inducible, Inserted expressed sequence | Gene | Tg(Myh6/tetO-Gsk3b*S9A)1Rbns |
| Induced With | doxycycline/tetracycline | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene contains constitutively active Gsk3b (an S9A mutation was introduced to make it constitutively active) under transcriptional control of a minimally active mouse alpha myosin heavy chain (Myh6) promoter fused to seven copies of the tetracycline-responsive promoter element (tetO). To make the Myh6 promoter minimally active, three GATA sites and two thyroid-like response elements are ablated. When bred with transgenic mice expressing a tetracycline transactivator or reverse transactivator protein, cardiac-specific expression of the constitutively active Gsk3b can be controlled by withdrawal or administration of a tetracycline analog. |
