| Primary Identifier | MGI:3759774 | Allele Type | Targeted |
| Attribute String | Conditional ready, Hypomorph | Gene | Mapk1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed PGK-neo cassette was inserted in reverse direction into intron 1 and an additional loxP site was inserted into intron 3. PCR genotyping was used to confirm insertion. Authors state that this is a hypomorphic allele. Western blot analysis of extracts from brain tissue confirmed a 20% to 40% reduction in protein expression that can be corrected by the removal of the neo cassette. |
