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Allele : Itgav<tm2.1Hyn> integrin alpha V; targeted mutation 2.1, Richard Hynes

Primary Identifier	MGI:3759837	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Itgav
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 4 was removed by cre-mediated recombination to create a null allele. Absence of protein expression was confirmed by FACS analysis of macrophages and splenocytes.

mutations:
Intragenic deletion

cellLines:
Not Specified

synonyms:
alphav<->,
alphav<->

earliestPublication:
McCarty JH, et al. (2005) Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 132(1):165-176

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

7 Publication categories

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