| First Author | Caucheteux SM | Year | 2013 |
| Journal | Proc Natl Acad Sci U S A | Volume | 110 |
| Issue | 5 | Pages | 1821-6 |
| PubMed ID | 23319636 | Mgi Jnum | J:193694 |
| Mgi Id | MGI:5469226 | Doi | 10.1073/pnas.1221306110 |
| Citation | Caucheteux SM, et al. (2013) Analysis of naive lung CD4 T cells provides evidence of functional lung to lymph node migration. Proc Natl Acad Sci U S A 110(5):1821-6 |
| abstractText | The proportion of CD4 T cells with phenotypic and functional properties of naive cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a delay of approximately 14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin prevents entry of naive CD4 T cells into the lung. Based on treatment with anti-CD62L and the use of CCR7(-/-) cells, lung naive CD4 T cells appear to migrate to the mediastinal lymph nodes along a CD62L-independent, CCR7-dependent pathway. Cells that have entered the node in this manner are competent to respond to antigen. Thus, a portion (approximately one-half) of naive CD4 T cells appears to enter the mediastinal lymph nodes through a blood-to-lung-to-lymph node route. |
