| First Author | Schmalzigaug R | Year | 2009 |
| Journal | Neurosci Lett | Volume | 451 |
| Issue | 2 | Pages | 156-61 |
| PubMed ID | 19114090 | Mgi Jnum | J:146556 |
| Mgi Id | MGI:3837906 | Doi | 10.1016/j.neulet.2008.12.034 |
| Citation | Schmalzigaug R, et al. (2009) Anxiety-like behaviors in mice lacking GIT2. Neurosci Lett 451(2):156-61 |
| abstractText | G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated GIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses. |
