| First Author | Mohri Y | Year | 2012 |
| Journal | Biosci Biotechnol Biochem | Volume | 76 |
| Issue | 5 | Pages | 888-91 |
| PubMed ID | 22738954 | Mgi Jnum | J:186318 |
| Mgi Id | MGI:5432040 | Doi | 10.1271/bbb.110834 |
| Citation | Mohri Y, et al. (2012) LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis. Biosci Biotechnol Biochem 76(5):888-91 |
| abstractText | In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys. To understand better the role of LGR4 in kidney development, we performed an analysis of kidneys in Lgr4<sup>-/-</sup> embryos. We stained Lgr4<sup>-/-</sup> kidneys with anti-WT1 and anti-Cleaved Caspase3 antibodies at E16.5, and observed that the structures of the cap mesenchyme were disrupted and that apoptosis increased. In addition, the expression of PAX2, an anti-apoptotic factor in kidney development, was also significantly decreased at E16.5. We found that the LGR4 defect caused an increase in apoptosis in the peripheral mesenchyme during kidney development. |
