Primary Identifier | MGI:3763211 | Allele Type | Targeted |
Attribute String | Inducible, Recombinase | Gene | Gt(ROSA)26Sor |
Transmission | Germline | Strain of Origin | C57BL/6NTac |
Induced With | tamoxifen | Is Recombinase | true |
Is Wild Type | false |
molecularNote | A fusion protein consisting of cre recombinase and the mutated ligand binding domain of the human estrogen receptor (ERT2) was inserted into intron 1. The estrogen receptor contains 3 mutations (G400V, M543A, L544A) that increase sensitivity to tamoxifen. |