| First Author | Taveirne S | Year | 2011 |
| Journal | J Leukoc Biol | Volume | 90 |
| Issue | 1 | Pages | 61-8 |
| PubMed ID | 21486908 | Mgi Jnum | J:174706 |
| Mgi Id | MGI:5140649 | Doi | 10.1189/jlb.1010581 |
| Citation | Taveirne S, et al. (2011) Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function. J Leukoc Biol 90(1):61-8 |
| abstractText | This study tested the hypothesis that Vgamma3 TCR-bearing T cells are influenced by LCs. Vgamma3 T cells and LCs are located in the epidermis of mice. Vgamma3 T cells represent the main T cell population in the skin epithelium and play a crucial role in maintaining the skin integrity, whereas LCs are professional APCs. Although Vgamma3 T cells and LCs form an interdigitating network in the epidermis, not much is known about their reciprocal influence and/or interdependence. We used two different LC-deficient mouse models, in which LCs are constitutively or inducibly depleted, to investigate the role of LCs in maturation, homeostasis, and function of Vgamma3 T cells. We show that Vgamma3 T cell numbers are unaltered by LC deficiency, and Vgamma3 T cells isolated from LC-deficient mice are phenotypically and upon in vitro stimulation, functionally indistinguishable from Vgamma3 T cells isolated from WT mice based on their cytotoxic potential and cytokine production. Additionally, in vivo skin-wounding experiments show no major difference in response of Vgamma3 T cells to wounding in the absence or presence of LCs. These observations indicate that Vgamma3 T cells develop and function independently of LCs. |
