| Primary Identifier | MGI:3762257 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Ccl19 |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| description | The gene targeting removed one CCL19 genes (the one with an atg start codon; CCL19a) but not the transcribed pseudogenes of CCL19 (acg start codon; CCL19b, CCL19c). Most or all CCL19 protein is gone in the mutant mice. |
| molecularNote | Nucleotides 38 through 120 of the second exon were replaced with a stop codon followed by an IRES-EGFP and a floxed neo cassette. The neo cassette was subsequently removed by cre-mediated recombination following a cross to mice carrying the cre gene driven by a beta-actin promoter (allele not specified). The absence of protein product was confirmed by western blot analysis on proteins extracted from the lymph nodes and spleen. |
