| First Author | Yang ZF | Year | 2007 |
| Journal | Nat Cell Biol | Volume | 9 |
| Issue | 3 | Pages | 339-46 |
| PubMed ID | 17277770 | Mgi Jnum | J:126422 |
| Mgi Id | MGI:3761232 | Doi | 10.1038/ncb1548 |
| Citation | Yang ZF, et al. (2007) The Ets transcription factor GABP is required for cell-cycle progression. Nat Cell Biol 9(3):339-46 |
| abstractText | The transition from cellular quiescence (G0) into S phase is regulated by the mitogenic-activation of D-type cyclins and cyclin-dependent kinases (Cdks), the sequestration of the Cdk inhibitors (CDKIs), p21 and p27, and the hyperphosphorylation of Rb with release of E2F transcription factors. However, fibroblasts that lack all D-type cyclins can still undergo serum-induced proliferation and key E2F targets are expressed at stable levels despite cyclical Rb-E2F activity. Here, we show that serum induces expression of the Ets transcription factor, Gabpalpha, and that its ectopic expression induces quiescent cells to re-enter the cell cycle. Genetic disruption of Gabpalpha prevents entry into S phase, and selectively reduces expression of genes that are required for DNA synthesis and degradation of CDKIs, yet does not alter expression of D-type cyclins, Cdks, Rb or E2Fs. Thus, GABP is necessary and sufficient for re-entry into the cell cycle and it regulates a pathway that is distinct from that of D-type cyclins and CDKs. |
