| Primary Identifier | MGI:3765440 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Hmgcr-MX1)LStae |
| Strain of Origin | (C57BL/6 x SJL)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Two founder lines were generated, "G" and "L". The only observed difference between the two lines is that breeding of the "G" line did not yield homozygous females. |
| molecularNote | Human cDNA encoding the cytoplasmic protein MX1 was put under the control of the murine Hmgcr promoter. Founder mice were generated with on a genetic background that lacks functional Mx1 and Mx2 genes. Transgenic mice expressed protein in the brain, heart, kidney, spleen, thymus, and lung. |
