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Other Genome Feature : Timo transgenic insertional mutants with obesity

Primary Identifier	MGI:3766098	Organism	mouse, laboratory
Chromosome	2	Mgi Type	unclassified other genome feature

description

PHENOTYPE: Homozygous mice display severe obesity, polyphagia, increased fat and lean mass, increased aggression to other mice, elevated leptin, insulin, cholesterol, and glucose levels, insulin resistance, and impaired glucose tolerance. Hemizygous mice show obesity and elevated LDL cholesterol. [provided by MGI curators]

synonyms:
Timo,
transgenic insertional mutants with obesity

earliestPublication:
Sha H, et al. (2007) Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice. Physiol Genomics 31(2):252-63

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