| First Author | Pak T | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 4 | Pages | e90381 |
| PubMed ID | 24699247 | Mgi Jnum | J:207455 |
| Mgi Id | MGI:5558912 | Doi | 10.1371/journal.pone.0090381 |
| Citation | Pak T, et al. (2014) Rax-CreERT2 Knock-In Mice: A Tool for Selective and Conditional Gene Deletion in Progenitor Cells and Radial Glia of the Retina and Hypothalamus. PLoS One 9(4):e90381 |
| abstractText | To study gene function in neural progenitors and radial glia of the retina and hypothalamus, we developed a Rax-CreERT2 mouse line in which a tamoxifen-inducible Cre recombinase is inserted into the endogenous Rax locus. By crossing Rax-CreERT2 with the Cre-dependent Ai9 reporter line, we demonstrate that tamoxifen-induced Cre activity recapitulates the endogenous Rax mRNA expression pattern. During embryonic development, Cre recombinase activity in Rax-CreERT2 is confined to retinal and hypothalamic progenitor cells, as well as progenitor cells of the posterior pituitary. At postnatal time points, selective Cre recombinase activity is seen in radial glial-like cell types in these organs |
