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Allele : Prkn<tm1Ccs> parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Christine C Stichel

Primary Identifier  MGI:3764690 Allele Type  Targeted
Attribute String  Null/knockout Gene  Prkn
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 3 was replaced with a neo-loxP cassette resulting in a frameshift mutation after amino acid 57. The shortened transcript was confirmed by RT-PCR analysis on brain tissue. The lack of protein production was confirmed by western blot analysis on total brain protein using a polyclonal antibody against the N-terminus.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • parkin<->,
  • pa<->,
  • parkin<->,
  • pa<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

9 Publication categories