| First Author | Thienel M | Year | 2023 |
| Journal | Science | Volume | 380 |
| Issue | 6641 | Pages | 178-187 |
| PubMed ID | 37053338 | Mgi Jnum | J:343016 |
| Mgi Id | MGI:7465232 | Doi | 10.1126/science.abo5044 |
| Citation | Thienel M, et al. (2023) Immobility-associated thromboprotection is conserved across mammalian species from bear to human. Science 380(6641):178-187 |
| abstractText | Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE. |
