| Primary Identifier | MGI:3765351 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The Thy1-APPKM670/671NL was constructed with the mutant human APPKM670/671NL cDNA (Swedish or KM670/671NL mutation of amyloid precursor protein (APP)) placed downstream of the murine Thy1.2 promoter region. Additionally, the Thy1-PS1L166P transgene was constructed with a mutant human PS1L166P cDNA (leucine to proline mutation at position 166 of human presenilin 1 (Alzheimer disease 3, PSEN1 or PS1)) placed downstream of the murine Thy1.2 promoter sequences. These constructs were coinjected to produce founder mice. In addition to line 21, lines 5 and 8 were also established. |
