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Allele : Tlr9<M2Btlr> toll-like receptor 9; mutation 2, Bruce Beutler

Primary Identifier  MGI:3767565 Allele Type  Chemically induced (ENU)
Gene  Tlr9 Inheritance Mode  Semidominant
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false Project Collection  Beutler Mutagenetix
molecularNote  The Cpg2 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is an A-to-T transversion at nucleotide position 3060 of the gene (Genbank Accession NM_031178) that results replacement of glutamine by leucine at amino acid position 985 of the receptor protein.
  • mutations:
  • Single point mutation
  • synonyms:
  • unmethylated CpG-oligodeoxynucleotide unresponsive 2,
  • CpG2,
  • Tlr9<CpG2>,
  • CpG2,
  • Tlr9<CpG2>,
  • unmethylated CpG-oligodeoxynucleotide unresponsive 2
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele