| Primary Identifier | MGI:3767575 | Allele Type | Chemically induced (ENU) |
| Gene | Tlr4 | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false | Project Collection | Beutler Mutagenetix |
| molecularNote | The lps3 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is an A-to-T transversion at nucleotide position 2147 of the gene (Genbank Accession NM_021297) that results in replacement of aspartic acid by valine at amino acid position 709 of the receptor protein. |
