| First Author | Nishijo N | Year | 1999 |
| Journal | Exp Anim | Volume | 48 |
| Issue | 3 | Pages | 203-8 |
| PubMed ID | 10480026 | Mgi Jnum | J:130451 |
| Mgi Id | MGI:3771690 | Doi | 10.1538/expanim.48.203 |
| Citation | Nishijo N, et al. (1999) Vascular remodeling in hypertensive transgenic mice. Exp Anim 48(3):203-8 |
| abstractText | We physiologically and histopathologically analyzed vascular damage due to hypertension and vascular remodeling in hypertensive transgenic mice (Tsukuba hypertensive mice; THM). Pubertal (6-week-old) THM already had hypertension similar to blood pressure in adult THM due to an enhanced renin angiotensin system (RAS). They progressively developed remarkable vascular hypertrophy composed of dedifferentiation of vascular smooth muscle cells (VSMCs) and extracellular matrix accumulation in the thoracic aorta, and VSMC hyperplasia was predominant in the abdominal aorta. THM are therefore a useful animal model for studying vascular remodeling mediated by enhanced RAS. |
