| Primary Identifier | MGI:3767608 | Allele Type | Targeted |
| Gene | Tgfbr1 | Transmission | Germline |
| Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The coding region was replaced with one containing a A to C substitution in exon 4 resulting in the substitution of alanine for aspartic acid at position 266 (D266A). This mutation prevents SMAD2 and SMAD3 activation but does not affect interacts with Acvrl1. RT-PCR analysis on spleen and liver was used to confirm the expression of the modified transcript. |
