Primary Identifier | MGI:3768527 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence, Modified isoform(s), Null/knockout | Gene | Mapt |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts replaced the endogenous mouse gene. Endogenous mouse Mapt protein is not expressed, and the inserted human gene is expressed in brain driven by a murine Thy1 promoter beginning at P15. |