| Primary Identifier | MGI:3767464 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Del(4Cdkn2a-Cdkn2b)2Brn |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | ES cells used possessed the Cdkn2atm1.1Brn and Cdkn2btm2Brn alleles on the same chromosome. |
| molecularNote | Germ line cre mediated recombination between the loxP site in Cdkn2btm2Brn and the loxP site in Cdkn2atm1.1Brn deleted a genomic segment encompassing the promoter of Cdkn2b and intron 2 of the Cdkn2a exon 1a. The absence of p15Ink4b, p16Ink4a and p19Arf protein products was confirmed by western blot analysis on mouse embryonic fibroblasts. |
