| First Author | Pilecka I | Year | 2007 |
| Journal | J Biol Chem | Volume | 282 |
| Issue | 48 | Pages | 35405-15 |
| PubMed ID | 17921143 | Mgi Jnum | J:128990 |
| Mgi Id | MGI:3768470 | Doi | 10.1074/jbc.M705814200 |
| Citation | Pilecka I, et al. (2007) Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth. J Biol Chem 282(48):35405-15 |
| abstractText | Several protein-tyrosine phosphatases (PTPs) have been implicated in the control of growth hormone receptor (GHR) signaling, but none have been shown to affect growth in vivo.We have applied a battery of molecular and cellular approaches to test a family-wide panel of PTPs for interference with GHR signaling. Among the subset of PTPs that showed activity in multiple readouts, we selected PTP-H1/PTPN3 for further in vivo studies and found that mice lacking the PTP-H1 catalytic domain show significantly enhanced growth over their wild type littermates. In addition, PTP-H1 mutant animals had enhanced plasma and liver mRNA expression of insulin-like growth factor 1, as well as increased bone density and mineral content. These observations point to a controlling role for PTP-H1 in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion. |
