| First Author | Oh J | Year | 2007 |
| Journal | J Dent Res | Volume | 86 |
| Issue | 12 | Pages | 1203-6 |
| PubMed ID | 18037656 | Mgi Jnum | J:130117 |
| Mgi Id | MGI:3771065 | Doi | 10.1177/154405910708601212 |
| Citation | Oh J, et al. (2007) A genome segment on mouse chromosome 12 determines maxillary growth. J Dent Res 86(12):1203-6 |
| abstractText | The primary and modifier genes that regulate normal maxillofacial development are unknown. Previous quantitative trait locus (QTL) analyses using the F2 progeny of 2 mouse strains, DBA/2J (short snout/wide face) and C57BL/6J (long snout/narrow face), revealed a significant logarithm-of-odds (LOD) score for snout length on mouse chromosome 12 at 44 centimorgan (cM). We further sought to validate this locus contributing to anterior-posterior dimensions of the upper mid-face at the D12Mit7 marker in a 44-centimorgan portion of chromosome 12. Congenic mice carrying introgressed DNA from DBA/2J on a C57BL/6J background were selected for submental vertex cephalometric imaging. Results confirmed QTLs, determining that short snout length (P < 0.05) and face width relative to snout length (P < 0.01) were present in the 44-cM region of chromosome 12. We conclude that one or more genes contributing to the shape of the maxillary complex are located near 44 cM of mouse chromosome 12. |
