| Primary Identifier | MGI:3772780 | Allele Type | Targeted |
| Attribute String | Conditional ready, Inserted expressed sequence, No functional change | Gene | Etv6 |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | This fusion product recapitulates the t(12;15)(p13;25q) translocation characteristic of human secretory breast carcinomas. |
| molecularNote | A floxed neo and stopper cassette along with the coding region of human NTRK3 from exon 6 with a polyadenylation signal was knocked into and replaced exon 6 and 7. The allele produces a fusion protein of the amino acids coded by the first 5 exons and protein tyrosine kinase domain of NTRK3. Expression of the fusion protein only occurs when the stopper cassette is removed by cre-mediated recombination. |
