| Primary Identifier | MGI:3770448 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Tln1 |
| Inheritance Mode | Recessive | Transmission | Germline |
| Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
| Is Wild Type | false |
| description | Cre recombinase-mediated deletion of the Neo cassette from the present, lethal mutation generates a floxed allele for which homozygosity has no adverse effect on survival or fertility. |
| molecularNote | A loxP-flanked neomycin resistance cassette (Neo) is present in intron 1, upstream of the first coding exon (exon 2), and a third loxP site resides downstream of the fourth coding exon (exon 5). Partial Cre-mediated recombination in vivo was used to delete only the floxed Neo cassette and create the Tln1tm4.1Crit allele. |
