Primary Identifier | MGI:3771152 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Myh6-NFKBIA*S32A*S36A)17Kykj |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The 1.1 kb human NFKBIA cDNA with two introduced point mutations at codons 32 and 36 (resulting in amino acid changes S32A and S36A) was subcloned between the 5.5 kb alpha-myosin heavy chain promoter and the 736 bp human growth hormone (Hgh) polyadenylation signal. Five founders with 1, 2 (line 17), 7 (line 44), 4 (line 151), and 7 (line 159) copies of the transgene were identified, but no offspring from the single copy number founder were obtained. |