| First Author | Christoffersen C | Year | 2018 |
| Journal | Cell Rep | Volume | 22 |
| Issue | 1 | Pages | 175-188 |
| PubMed ID | 29298420 | Mgi Jnum | J:271256 |
| Mgi Id | MGI:6278485 | Doi | 10.1016/j.celrep.2017.12.029 |
| Citation | Christoffersen C, et al. (2018) The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity. Cell Rep 22(1):175-188 |
| abstractText | Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or beta3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism. |
