| Primary Identifier | MGI:3772577 | Allele Type | Transgenic |
| Attribute String | Inducible, Inserted expressed sequence | Gene | Tg(tetO-Mcpt1)1Mrab |
| Strain of Origin | Not Specified | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The transgene was designed with the tetracycline-responsive element (TRE; also called tet-operator or tetO) upstream of a rat vascular chymase (RVCH or Mcpt1) gene modified such that a human influenza hemagglutinin (HA) tag is added to the C terminus of mature RVCH protein. With the addition of dox expression of the RVCH-HA fusion protein can be completely abolished, reversing the hypertension phenotype. |
