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Allele : Tg(tetO-Mcpt1)1Mrab transgene insertion 1, Marlene Rabinovitch
Primary Identifier  MGI:3772577 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(tetO-Mcpt1)1Mrab
Strain of Origin  Not Specified Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  The transgene was designed with the tetracycline-responsive element (TRE; also called tet-operator or tetO) upstream of a rat vascular chymase (RVCH or Mcpt1) gene modified such that a human influenza hemagglutinin (HA) tag is added to the C terminus of mature RVCH protein. With the addition of dox expression of the RVCH-HA fusion protein can be completely abolished, reversing the hypertension phenotype.
  • mutations:
  • Insertion
  • synonyms:
  • TRE-RVCH-HA,
  • RVCH+,
  • TRE-RVCH-HA,
  • RVCH+
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

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0 Driven By

3 Publication categories

Trail: Allele




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