| Primary Identifier | MGI:3773076 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(Nkx2-1-cre)2Sand |
| Strain of Origin | C57BL/6 | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | A mouse BAC clone containing the Nkx2-1 gene was engineered to express cre recombinase. Fifteen base pairs at the 5'end of exon 2 of the Nkx2-1 gene were replaced with a cre-poly(A) construct. The mutated BAC clone was then used to generate transgenic mice. This construct is expressed in brain, thyroid, pituitary, and lung, with telecephalic expression first detectable at E10.5. |
