| First Author | Kuwahara M | Year | 2012 |
| Journal | Nat Immunol | Volume | 13 |
| Issue | 8 | Pages | 778-86 |
| PubMed ID | 22751141 | Mgi Jnum | J:187632 |
| Mgi Id | MGI:5437570 | Doi | 10.1038/ni.2362 |
| Citation | Kuwahara M, et al. (2012) The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-beta and suppresses T(H)2 differentiation. Nat Immunol 13(8):778-86 |
| abstractText | Sox4 is a transcription factor that regulates various developmental processes. Here we show that Sox4 was induced by TGF-beta and negatively regulated the transcription factor GATA-3, the master regulator of function of T helper type 2 (T(H)2) cells, by two distinct mechanisms. First, Sox4 bound directly to GATA-3, preventing its binding to GATA-3 consensus DNA sequences. Second, Sox4 bound to the promoter region of the gene encoding interleukin 5 (IL-5), a T(H)2 cytokine, and prevented binding of GATA-3 to this promoter. T(H)2 cell-driven airway inflammation was modulated by alterations in Sox4 expression. Thus, Sox4 acted as a downstream target of TGF-beta to inhibit GATA-3 function, T(H)2 differentiation and T(H)2 cell-mediated inflammation. |
