| Primary Identifier | MGI:3773036 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Kcnq1ot1 |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Five evolutionarily conserved 30-bp repeated sequences in the proximal end of the transcript were deleted in a 657 bp region. A self-excising selection cassette was also placed downstream of the gene. After recombination and generation of chimeric mice, the selection cassette excised itself in the male germline leaving behind a single loxP site. Heterozygous mice that inherit the deletion paternally transcribe a truncated RNA that is missing the 657 bp of sequence but is otherwise a full length transcript. |
