| First Author | Mori H | Year | 2024 |
| Journal | Mol Metab | Volume | 83 |
| Pages | 101916 | PubMed ID | 38492843 |
| Mgi Jnum | J:346627 | Mgi Id | MGI:7617825 |
| Doi | 10.1016/j.molmet.2024.101916 | Citation | Mori H, et al. (2024) Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes. Mol Metab 83:101916 |
| abstractText | OBJECTIVE: Exposure of adipocytes to 'cool' temperatures often found in the periphery of the body induces expression of Stearoyl-CoA Desaturase-1 (Scd1), an enzyme that converts saturated fatty acids to monounsaturated fatty acids. The goal of this study is to further investigate the roles of Scd in adipocytes. METHOD: In this study, we employed Scd1 knockout cells and mouse models, along with pharmacological Scd1 inhibition to dissect the enzyme's function in adipocyte physiology. RESULTS: Our study reveals that production of monounsaturated lipids by Scd1 is necessary for fusion of autophagosomes to lysosomes and that with a Scd1-deficiency, autophagosomes accumulate. In addition, Scd1-deficiency impairs lysosomal and autolysosomal acidification resulting in vacuole accumulation and eventual cell death. Blocking autophagosome formation or supplementation with monounsaturated fatty acids maintains vitality of Scd1-deficient adipocytes. CONCLUSION: This study demonstrates the indispensable role of Scd1 in adipocyte survival, with its inhibition in vivo triggering autophagy-dependent cell death and its depletion in vivo leading to the loss of bone marrow adipocytes. |
