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Allele : Phox2b<tm2Jbr> paired-like homeobox 2b; targeted mutation 2, Jean-Francois Brunet

Primary Identifier  MGI:3773691 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Phox2b
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 3 was replaced with an exon 3 that contained a 7 alanine expansion of a 20-residue polyalanine chain, mimicking a mutatation found in some congenital central hypoventilation syndrome (CCHS) patients. A floxed neo cassette was also inserted downstream of exon 3.
  • mutations:
  • Insertion
  • synonyms:
  • Phox2b<27Ala>,
  • Phox2b<27Ala>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories