Primary Identifier | MGI:3773691 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Phox2b |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 3 was replaced with an exon 3 that contained a 7 alanine expansion of a 20-residue polyalanine chain, mimicking a mutatation found in some congenital central hypoventilation syndrome (CCHS) patients. A floxed neo cassette was also inserted downstream of exon 3. |