| Primary Identifier | MGI:3774129 | Allele Type | Chemically induced (ENU) |
| Gene | Irak4 | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false | Project Collection | Beutler Mutagenetix |
| molecularNote | The otiose mutation, which was identified in an ENU mutagenesis screen for mutants with altered responses to Toll-like receptor (TLR) ligands, corresponds to a T to C transition at nucleotide position 1095 of the gene, in exon 9 of 12 total exons. No immunoreactive protein is detected by western blot analysis of mutant macrophages, and immunoprecipitated protein from mutant macrophages exhibits no kinase activity in vitro. |
