| Primary Identifier | MGI:3774140 | Allele Type | Chemically induced (ENU) |
| Gene | Tlr9 | Inheritance Mode | Other (see notes) |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false | Project Collection | Beutler Mutagenetix |
| description | The inheritance of the mutant phenotype is probably semidominant, like that of other Tlr9 mutations; however, homozygous mutants have not been examined. |
| molecularNote | The mutant phenotype, discovered in an ENU mutagenesis screen for impaired response of peritoneal macrophages to Toll-like receptor (TLR) ligands, is due to a T-to-C transition at nucleotide position 1284 (Genbank Accession NM_031178) in the second of two exons. It results in replacement of leucine by proline at amino acid position 393 (L393P), the initial leucine in the fourteenth extracellular leucine-rich repeat of the receptor's ectodomain. |
