| First Author | Levin ED | Year | 2005 |
| Journal | Behav Genet | Volume | 35 |
| Issue | 4 | Pages | 447-53 |
| PubMed ID | 15971025 | Mgi Jnum | J:129151 |
| Mgi Id | MGI:3768743 | Doi | 10.1007/s10519-004-1510-y |
| Citation | Levin ED, et al. (2005) Memory decline of aging reduced by extracellular superoxide dismutase overexpression. Behav Genet 35(4):447-53 |
| abstractText | Extracellular superoxide dismutase (EC-SOD) plays an important role in controlling oxidative stress as well as intercellular signaling. In the current study, we tested the effect of EC-SOD overexpression over the lifespan of a set of mice and their wild-type controls to determine the time scale over which EC-SOD overexpression might attenuate aging-induced memory impairment. Mice with overexpression of EC-SOD and wild-type controls were initially trained on the radial-arm maze as young adults (3-5 months) and then retrained during middle age (12-14 months) and retested in old age at 27 and 30 months. There was little EC-SOD effect during the young adult middle age periods. EC-SOD overexpression prevented the decline in choice accuracy when the mice were 27-30 months of age. The EC-SOD overexpressing mice maintained their performance, while the wild-type mice declined to naive levels of performance by 30 months of age. Enhancement of EC-SOD activity appears to improve memory performance specifically in aging mice. EC-SOD mimetic treatment during the course of aging may hold promise for aging-induced cognitive impairment. |
